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A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures.

Clinical Studies
Rossignol, D.A., Frye, R.E. Mol Psychiatry. 2012; 17(4):389-401. Read Article

Substantial problems with measuring brain mitochondrial dysfunction in autism spectrum disorder using magnetic resonance spectroscopy.

Clinical Studies
Rossignol, D.A., Frye, R.E. J Autism Dev Disord. 2012; 42(4):640-2. Read Article

Developmental regression and mitochondrial dysfunction in a child with autism.

Case Studies
Poling, J.S., Frye, R.E., Shoffner, J., Zimmerman, A.W. J Child Neurol. 2006; 21(2):170-2. Read Article

Mitochondrial disease in 22q13 duplication syndrome.

Case Studies
Frye RE. J Child Neurol. 2012; 27(7):942-9. Read Article

Mitochondrial Dysfunction may explain symptom variation in Phelan-McDermid Syndrome.

Case Studies
Frye, R.E., Cox, D., Slattery, J., Tippett, M., Kahler, S., Granpeesheh, D., Damle, S., Legido, A., Goldenthal, M.J. Sci Re...

Autistic Siblings with Novel Mutations in Two Different Genes: Insight for Genetic Workups of Autistic Siblings and Connection to Mitochondrial Dysfunction.

Case Studies
Burger, B.J., Rose, S., Bennuri, S.C., Gill, P.S., Tippett, M.L., Delhey, L., Melnyk, S., Frye, R.E.. Front Pediatr. 2017; ...

Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study.

Cellular Models
Rose, S., Bennuri, S.C., Wynne, R., Melnyk, S., James, S.J., Frye, R.E. FASEB J. 2017; 31(3):904-909. Read Article

Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines.

Cellular Models
Rose, S., Frye, R.E., Slattery, J., Wynne, R., Tippett, M., Melnyk, S., James, S.J. Transl Psychiatry. 2014; 4:e377. Read ...

Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort.

Cellular Models
Rose, S., Frye, R.E., Slattery, J., Wynne, R., Tippett, M., Pavliv, O., Melnyk, S., James, S.J. PLoS One. 2014; 9(1):e85436...

Oxidative Stress Challenge Uncovers Trichloroacetaldehyde Hydrate-Induced Mitoplasticity in Autistic and Control Lymphoblastoid Cell Lines.

Toxicants
Frye, R.E., Rose, S., Wynne, R., Bennuri, S.C., Blossom, S., Gilbert, K.M., Heilbrun, L., Palmer, R.F. Sci Rep. 2017; 7(1):...

Increased susceptibility to ethylmercury-induced mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines.

Toxicants
Rose, S., Wynne, R., Frye, R.E., Melnyk, S., James, S.J. J Toxicol. 2015; 2015:573701. Read Article

Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism.

Enteric Short Chain Fatty Acids
Rose, S., Bennuri, S..C, Davis, J.E., Wynne, R., Slattery, J.C., Tippett, M., Delhey, L., Melnyk, S., Kahler, S.G., MacFabe...
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The Autism Discovery and Treatment Foundation (ADTF) is a 501c organization dedicated to solving complex medical problems. The overall aim of ADTF is to improve the lives of individuals and families living with chronic diseases which have been difficult to treat and/or cure. Our focus is on autism and other neurodevelopmental disorders.
Info@autismdiscovery.org

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