Clinical Studies

Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder.

Clinical Studies

Rose S, Niyazov DM, Rossignol DA, Goldenthal M, Kahler SG, Frye RE. Mol Diagn Ther. 2018 Oct;22(5):571-593.

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Mitochondrial Dysfunction in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis.

Clinical Studies

Rossignol, D., Frye, R.E. Molecular Psychiatry, 2012; 17(3):290-314. DOI: 10.1038/mp.2010.136. PMID: 21263444

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Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders.

Clinical Studies

Frye, R.E., Rossignol, D.A. Pediatr Res. 2011; 69(5 Pt 2):41R-7R.

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Redox Metabolism Abnormalities in Autistic Children Associated with Mitochondrial Disease

Clinical Studies

Frye, R.E., DeLaTorre, R. Taylor, H. Slattery, J., Melnyk, S. James, S.J.Translational Psychiatry, 2013 3:e273. DOI: 10.1038/tp.2013.51. PMID: 23778583

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Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study.

Clinical Studies

Rose, S., Bennuri, S.C., Murray, K.F., Buie, T., Winter, H., Frye, R.E. PLoS One. 2017 Oct 13;12(10):e0186377.

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Bioenergetic variation is related to autism symptomatology.

Clinical Studies

Delhey, L., Kilinc, E.N., Yin, L., Slattery, J., Tippett, M., Wynne, R., Rose, S., Kahler, S., Damle, S., Legido, A., Goldenthal, M.J., Frye, R.E.. Metab Brain Dis. 2017; 32(6):2021-2031.

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Novel biomarkers of metabolic dysfunction is autism spectrum disorder: potential for biological diagnostic markers.

Clinical Studies

Khemakhem, A.M., Frye, R.E., El-Ansary, A., Al-Ayadhi, L., Bacha, A.B. Metab Brain Dis. 2017; 32(6):1983-1997.

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The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder.

Clinical Studies

Delhey, L.M., Nur Kilinc, E., Yin, L., Slattery, J.C., Tippett, M.L., Rose, S., Bennuri, S.C., Kahler, S.G., Damle, S., Legido, A., Goldenthal, M.J., Frye, R.E. J Clin Med. 2017; 6(2). pii: E18.

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Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome.

Clinical Studies

Frye, R.E., Rose, S., Slattery, J., MacFabe, D.F. Microb Ecol Health Dis. 2015; 26:27458.

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Metabolic and mitochondrial disorders associated with epilepsy in children with autism spectrum disorder.

Clinical Studies

Frye RE. Epilepsy Behav. 2015; 47:147-57.

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Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism.

Clinical Studies

Rossignol, D.A., Frye, R.E. Front Physiol. 2014; 22;5:150.

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Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder.

Clinical Studies

Frye, R.E., Melnyk, S., Macfabe, D.F. Transl Psychiatry. 2013; 3:e220.

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A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures.

Clinical Studies

Rossignol, D.A., Frye, R.E. Mol Psychiatry. 2012; 17(4):389-401.

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Substantial problems with measuring brain mitochondrial dysfunction in autism spectrum disorder using magnetic resonance spectroscopy.

Clinical Studies

Rossignol, D.A., Frye, R.E. J Autism Dev Disord. 2012; 42(4):640-2.

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