Mitochondrial Research

Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder.

Clinical Studies

Rose S, Niyazov DM, Rossignol DA, Goldenthal M, Kahler SG, Frye RE. Mol Diagn Ther. 2018 Oct;22(5):571-593.

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Mitochondrial Dysfunction in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis.

Clinical Studies

Rossignol, D., Frye, R.E. Molecular Psychiatry, 2012; 17(3):290-314. DOI: 10.1038/mp.2010.136. PMID: 21263444

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Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders.

Clinical Studies

Frye, R.E., Rossignol, D.A. Pediatr Res. 2011; 69(5 Pt 2):41R-7R.

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Redox Metabolism Abnormalities in Autistic Children Associated with Mitochondrial Disease

Clinical Studies

Frye, R.E., DeLaTorre, R. Taylor, H. Slattery, J., Melnyk, S. James, S.J.Translational Psychiatry, 2013 3:e273. DOI: 10.1038/tp.2013.51. PMID: 23778583

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Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study.

Clinical Studies

Rose, S., Bennuri, S.C., Murray, K.F., Buie, T., Winter, H., Frye, R.E. PLoS One. 2017 Oct 13;12(10):e0186377.

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Bioenergetic variation is related to autism symptomatology.

Clinical Studies

Delhey, L., Kilinc, E.N., Yin, L., Slattery, J., Tippett, M., Wynne, R., Rose, S., Kahler, S., Damle, S., Legido, A., Goldenthal, M.J., Frye, R.E.. Metab Brain Dis. 2017; 32(6):2021-2031.

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Novel biomarkers of metabolic dysfunction is autism spectrum disorder: potential for biological diagnostic markers.

Clinical Studies

Khemakhem, A.M., Frye, R.E., El-Ansary, A., Al-Ayadhi, L., Bacha, A.B. Metab Brain Dis. 2017; 32(6):1983-1997.

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The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder.

Clinical Studies

Delhey, L.M., Nur Kilinc, E., Yin, L., Slattery, J.C., Tippett, M.L., Rose, S., Bennuri, S.C., Kahler, S.G., Damle, S., Legido, A., Goldenthal, M.J., Frye, R.E. J Clin Med. 2017; 6(2). pii: E18.

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Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome.

Clinical Studies

Frye, R.E., Rose, S., Slattery, J., MacFabe, D.F. Microb Ecol Health Dis. 2015; 26:27458.

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Metabolic and mitochondrial disorders associated with epilepsy in children with autism spectrum disorder.

Clinical Studies

Frye RE. Epilepsy Behav. 2015; 47:147-57.

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Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism.

Clinical Studies

Rossignol, D.A., Frye, R.E. Front Physiol. 2014; 22;5:150.

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Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder.

Clinical Studies

Frye, R.E., Melnyk, S., Macfabe, D.F. Transl Psychiatry. 2013; 3:e220.

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A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures.

Clinical Studies

Rossignol, D.A., Frye, R.E. Mol Psychiatry. 2012; 17(4):389-401.

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Substantial problems with measuring brain mitochondrial dysfunction in autism spectrum disorder using magnetic resonance spectroscopy.

Clinical Studies

Rossignol, D.A., Frye, R.E. J Autism Dev Disord. 2012; 42(4):640-2.

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Developmental regression and mitochondrial dysfunction in a child with autism.

Case Studies

Poling, J.S., Frye, R.E., Shoffner, J., Zimmerman, A.W. J Child Neurol. 2006; 21(2):170-2.

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Mitochondrial disease in 22q13 duplication syndrome.

Case Studies

Frye RE. J Child Neurol. 2012; 27(7):942-9.

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Mitochondrial Dysfunction may explain symptom variation in Phelan-McDermid Syndrome.

Case Studies

Frye, R.E., Cox, D., Slattery, J., Tippett, M., Kahler, S., Granpeesheh, D., Damle, S., Legido, A., Goldenthal, M.J. Sci Rep. 2016 Jan 29;6:19544.

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Autistic Siblings with Novel Mutations in Two Different Genes: Insight for Genetic Workups of Autistic Siblings and Connection to Mitochondrial Dysfunction.

Case Studies

Burger, B.J., Rose, S., Bennuri, S.C., Gill, P.S., Tippett, M.L., Delhey, L., Melnyk, S., Frye, R.E.. Front Pediatr. 2017; 5:219.

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Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study.

Cellular Models

Rose, S., Bennuri, S.C., Wynne, R., Melnyk, S., James, S.J., Frye, R.E. FASEB J. 2017; 31(3):904-909.

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Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines.

Cellular Models

Rose, S., Frye, R.E., Slattery, J., Wynne, R., Tippett, M., Melnyk, S., James, S.J. Transl Psychiatry. 2014; 4:e377.

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Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort.

Cellular Models

Rose, S., Frye, R.E., Slattery, J., Wynne, R., Tippett, M., Pavliv, O., Melnyk, S., James, S.J. PLoS One. 2014; 9(1):e85436.

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Oxidative Stress Challenge Uncovers Trichloroacetaldehyde Hydrate-Induced Mitoplasticity in Autistic and Control Lymphoblastoid Cell Lines.

Toxicants

Frye, R.E., Rose, S., Wynne, R., Bennuri, S.C., Blossom, S., Gilbert, K.M., Heilbrun, L., Palmer, R.F. Sci Rep. 2017; 7(1):4478.

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Increased susceptibility to ethylmercury-induced mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines.

Toxicants

Rose, S., Wynne, R., Frye, R.E., Melnyk, S., James, S.J. J Toxicol. 2015; 2015:573701.

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Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism.

Enteric Short Chain Fatty Acids

Rose, S., Bennuri, S..C, Davis, J.E., Wynne, R., Slattery, J.C., Tippett, M., Delhey, L., Melnyk, S., Kahler, S.G., MacFabe, D.F., Frye, R.E.. Transl Psychiatry. 2018; 8(1):42.

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Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines.

Enteric Short Chain Fatty Acids

Frye, R.E., Rose, S., Chacko. J, Wynne, R., Bennuri, S.C., Slattery, J.C., Tippett, M., Delhey, L,. Melnyk, S., Kahler, S.G., MacFabe, D.F. Transl Psychiatry. 2016; 6(10):e927.

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