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Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder.

Clinical Studies
Rose S, Niyazov DM, Rossignol DA, Goldenthal M, Kahler SG, Frye RE. Mol Diagn Ther. 2018 Oct;22(5):571-593. Read Article ...

Mitochondrial Dysfunction in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis.

Clinical Studies
Rossignol, D., Frye, R.E. Molecular Psychiatry, 2012; 17(3):290-314. DOI: 10.1038/mp.2010.136. PMID: 21263444 Read Article...

Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders.

Clinical Studies
Frye, R.E., Rossignol, D.A. Pediatr Res. 2011; 69(5 Pt 2):41R-7R. Read Article

Redox Metabolism Abnormalities in Autistic Children Associated with Mitochondrial Disease

Clinical Studies
Frye, R.E., DeLaTorre, R. Taylor, H. Slattery, J., Melnyk, S. James, S.J.Translational Psychiatry, 2013 3:e273. DOI: 10.103...

Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study.

Clinical Studies
Rose, S., Bennuri, S.C., Murray, K.F., Buie, T., Winter, H., Frye, R.E. PLoS One. 2017 Oct 13;12(10):e0186377. Read Articl...

Bioenergetic variation is related to autism symptomatology.

Clinical Studies
Delhey, L., Kilinc, E.N., Yin, L., Slattery, J., Tippett, M., Wynne, R., Rose, S., Kahler, S., Damle, S., Legido, A., Golde...

Novel biomarkers of metabolic dysfunction is autism spectrum disorder: potential for biological diagnostic markers.

Clinical Studies
Khemakhem, A.M., Frye, R.E., El-Ansary, A., Al-Ayadhi, L., Bacha, A.B. Metab Brain Dis. 2017; 32(6):1983-1997. Read Articl...

The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder.

Clinical Studies
Delhey, L.M., Nur Kilinc, E., Yin, L., Slattery, J.C., Tippett, M.L., Rose, S., Bennuri, S.C., Kahler, S.G., Damle, S., Leg...

Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome.

Clinical Studies
Frye, R.E., Rose, S., Slattery, J., MacFabe, D.F. Microb Ecol Health Dis. 2015; 26:27458. Read Article

Metabolic and mitochondrial disorders associated with epilepsy in children with autism spectrum disorder.

Clinical Studies
Frye RE. Epilepsy Behav. 2015; 47:147-57. Read Article

Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism.

Clinical Studies
Rossignol, D.A., Frye, R.E. Front Physiol. 2014; 22;5:150. Read Article

Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder.

Clinical Studies
Frye, R.E., Melnyk, S., Macfabe, D.F. Transl Psychiatry. 2013; 3:e220. Read Article
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The Autism Discovery and Treatment Foundation (ADTF) is a 501c organization dedicated to solving complex medical problems. The overall aim of ADTF is to improve the lives of individuals and families living with chronic diseases which have been difficult to treat and/or cure. Our focus is on autism and other neurodevelopmental disorders.
Info@autismdiscovery.org

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