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A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures.

Rossignol, D.A., Frye, R.E. Mol Psychiatry. 2012; 17(4):389-401. Read Article

Substantial problems with measuring brain mitochondrial dysfunction in autism spectrum disorder using magnetic resonance spectroscopy.

Rossignol, D.A., Frye, R.E. J Autism Dev Disord. 2012; 42(4):640-2. Read Article

Developmental regression and mitochondrial dysfunction in a child with autism.

Poling, J.S., Frye, R.E., Shoffner, J., Zimmerman, A.W. J Child Neurol. 2006; 21(2):170-2. Read Article

Mitochondrial disease in 22q13 duplication syndrome.

Frye RE. J Child Neurol. 2012; 27(7):942-9. Read Article

Mitochondrial Dysfunction may explain symptom variation in Phelan-McDermid Syndrome.

Frye, R.E., Cox, D., Slattery, J., Tippett, M., Kahler, S., Granpeesheh, D., Damle, S., Legido, A., Goldenthal, M.J. Sci Rep. 2016 Jan 29;6:19544. Read Article

Autistic Siblings with Novel Mutations in Two Different Genes: Insight for Genetic Workups of Autistic Siblings and Connection to Mitochondrial Dysfunction.

Burger, B.J., Rose, S., Bennuri, S.C., Gill, P.S., Tippett, M.L., Delhey, L., Melnyk, S., Frye, R.E.. Front Pediatr. 2017; 5:219. Read Article